Posts Tagged ‘Vemurafenib’:

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with unique driver mutations.

Niehr F, von Euw E, Attar N, Guo D, Matsunaga D, Sazegar H, Ng C, Glaspy JA, Recio JA, Lo RS, Mischel PS, Comin-Anduix B, Ribas A. “J Transl Med. 2011 May ” BACKGROUND: A molecular linkage in between the MAPK and also the LKB1-AMPK power sensor pathways suggests that blended MAPK oncogene inhibition and

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Vemurafenib is verified to trigger programmed cell dying in melanoma cell lines

Shi H, Kong X, Ribas A, Lo RS. “Cancer Res. 2011 Aug” Vemurafenib is verified to trigger programmed cell dying in melanoma cell lines. Vemurafenib interrupts the B-Raf/MEK stage on the B-Raf/MEK/ERK pathway ? when the B-Raf has the prevalent V600E mutation. Vemurafenib only capabilities in melanoma people whose cancer capabilities a V600E BRAF mutation

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