Target of rapamycin (TOR) kinase is an evolutionarily conserved master regulator that integrates energy, nutrients, growth factors and pressure signals to promote survival and growth in all eukaryotes. The reported land plant resistance to rapamycin as well as the embryo lethality of the Arabidopsis tor mutants have hindered functional dissection of TOR signaling in plants.
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Tabatabaian F, Dougherty K, Di Fulvio M, Gomez Cambronero J “The Journal of Biological Chemistry ” 2010 The mammalian goal of rapamycin (mTOR) and S6 kinase (S6K) pathway is essential for cell differentiation, growth, and survival. Phospholipase D2 (PLD2) performs a key part in mTOR/S6K mitogenic signaling. However, the influence of PLD on mTOR/S6K gene
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Yip CK, Murata K, Walz T, Sabatini DM, Kang SA “Molecular cell 2010″ The rapamycin-sensitive mTOR complex 1 (mTORC1) encourages protein synthesis, cell growth, and cell proliferation in response to growth elements and dietary cues. To elucidate the badly defined mechanisms underlying mTORC1 regulation, we have studied the phosphorylation of raptor, an mTOR-interacting companion. We
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