Posts Tagged ‘p53’:

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods.

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods. Source Inserm UMR-S 973/MTi, University Paris Diderot, Paris, France. Abstract Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with

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Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

Nalls D, Tang SN, Rodova M, Srivastava RK, Shankar S. “PLoS 1. 2011 Aug” BACKGROUND: MicroRNA-34a (miR-34a) can be a transcriptional target of p53 and it is down-regulated in pancreatic cancer. This research aimed to research the functional significance of miR-34a in pancreatic cancer progression via its epigenetic restoration with chromatin modulators, demethylating agent 5-Aza-2′-deoxycytidine

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TGF-β signaling encourages hepatocarcinogenesis induced by p53 loss

Morris SM, Baek JY, Koszarek A, Kanngurn S, Knoblaugh SE, Grady WM. “Hepatology. 2011 Sep” Hepatocellular carcinoma (HCC) outcomes from the accumulation of deregulated tumor suppressor genes and/or oncogenes in hepatocytes. Inactivation of TP53 and inhibition of transforming development factor-beta (TGF-β) signaling are among the most typical molecular events in human liver cancers. Therefore, we

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© Apoptosis|apoptosis inhibitor|apoptosis pathway
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