Posts Tagged ‘AZD-2281’:

Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells.

Senra JM, Telfer BA, Cherry KE, McCrudden CM, Hirst DG, O’Connor MJ, Wedge SR, Stratford IJ. “Mol Cancer Ther. 2011 Oct ” PARP-1 inhibitor is really a critical enzyme inside the repair of DNA strand breaks. Inhibition of PARP-1 raises the effectiveness of radiation in killing tumor cells. Nonetheless, although the mechanism(s) are well understood

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