patients with high cardiovascular risks. Downloaded from hyper.ahajournals/ by guest on March 7, Online ARRY-520 Supplementparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance: NAGOYA HEART Study Takashi Muramat PhD; Kunihiro Matsushi PhD; Kentaro Yamashi MD; Takahisa Kon PhD; Kengo Mae PhD; Satoshi Shinta PhD; Satoshi Ichimi PhD; Miyoshi Oh PhD; Takahito So PhD; Nobuo Ike PhD; Masato Watar MD; Toyoaki Muroha P the NAGOYA HEART Study Investigators Expanded Materials and Methods Exclusion criteria Patients with the following conditions were excluded from the study: prior CVD within months; taking CCB for angina pectoris; left ventricular ejection fraction < 0; atrioventricular block; secondary or severe hypertensio.
serum creatinine ‰ ? mol/L; pregnant women; life expectancy less than years; or other conditions for which physicians judged it inappropriate to enroll patients. Procedures and follow up Patients were followed up every month in the first months and then every to months. Pre-specified measuremen prescribed medicatio and clinical events were reported to the Data Management Nepafenac clinical trial Center every months. We also made clinical research coordinators visit regularly to collect and reconfirm the reported data. Even when patients had std visiting institutio CRC checked up their health status by either letter or phone call. Final the CRC group managed institutions and / patients . Interim analyses and data monitoring The interim analyses were assessed immediately after closing the enrollment and every months .
The Data and Safety Monitoring Board independently monitored every updated result and suggested to continue or to close this study. The prespecified conditions to close this study were as follows: the difference of effects in the Marbofloxacin structure two treatment groups were shown to be statistically significan. the number of incident CVD reached more than we anticipate. median follow-up period reached more than years; or any serious adverse events that might threaten the safety of study continuation were observed. Downloaded from hyper.ahajournals/ by guest on March 7, Downloaded from hyper.ahajournals/ by guest on March 7, Table .
Adverse events in safety analysis Adverse events Solid cancer Dizziness Liver dysfunction Aortic aneurysm Headache Rashes / Zoster Benign tumor Fulvestrant solubility Fracture Face flush Fatigue Hyperkalemia Atrioventricular block Gastric ulcer Pruritis Dry cough Angioedema Gingival hypertrophy Total events Valsartan group 6 Amlodipine group 2indicates number. Downloaded from hyper.ahajournals by guest on March 7, Clinical Significance of Incident Hypokalemia and Hyperkalemia in Treated Hypertensive Patients in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Michael H. for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative option style Research Group See Editorialmenta Concerns exist that diuretic-induced changes in serum potassium may have adverse effects in hypertensive patients.
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