The accumulation Images of the static and time series were examined using an Olympus FV1000 Ma based on a confocal microscope BX61 WI. A target 20 XLUMPLFLN immersion in water and 60 LUMFLN water immersion objective were used for data collection. BO and H2B masitinib AB1010 Apple-FL were digitized and sequentially excited using a 473 nm diode laser and 559 nm, in combination with a DM405/488/559/635 nm dichroic beam splitter The. The emitted light was then separated and collected using a beam splitter and BA490 BA575 SDM560 675 540 and bandpass filter. Tumors of control To have been used to ensure the image forming conditions that no fading or Phototoxizit t optimize the imaging parameters relied. Biodistribution of 18F BO-B6 Mice were provisions for Half-Blood found life use.
The Mice were intravenously 34 5 Ci of 18F BO Se administered tail vein. Blood collection was retro-orbital GSK690693 puncture with calibrated, heparinized Kapillarr Performed Hrchen. The samples were then weighed and the activity of t was measured using an automatic gamma-Z Counter. Half-life data have been adjusted to blood in a biexponential model, and the results are reported as weighted mean of the distribution and release phases. For biodistributions were B6-M Mice intravenously S injected via the tail vein with either 43 or 22 5410 Ci Ci 18F BO. The animals were then get with 2 or 18 hours after the injection Tet, respectively. The tissues were then harvested and weighed, and the radioactivity t gez was just increments using the PerkinElmer Wallac Wizard 3 � 1480 Automatic Gamma Counter.
Statistical analysis was performed using GraphPad Prism 4.0c. PET-CT imaging Mice were imaged with the PET scanner with a scanner for small animals Inveon. Each PET acquisition lasted about 25 minutes. A high res Sive Fourier rebinning algorithm was Rebin sinograms by a filtered back projection algorithm uses three-dimensional images without sw To reconstruct deviation correction followed. Isotropic Voxelgr S image was 0.796 0.861 mm 0861, for a total of 128 128 159 voxels. The maximum sensitivity of 11.1% represents Inveon emission tomography, with an average resolution and high of 1.65 mm. More than 100 Z Hlungen were detected per pixel and the average signal-to-noise ratio Ratio above 20 The calibration of the PET signal with a cylindrical air neoplasia child Including me.
14, No. 3, 2012 In vivo imaging of PARP inhibition therapy Reiner et al. 18F-171 isotope was conducted reconstructed primarily of 360 Scans.CTimageswere c Projections do R Ntgenstrahl with a capacity of 80 keV and 500 A. isotropic resolution and high of CT images was 60 m. Reconstruction of data records COLUMNS, PET-CT fusion, and image analysis were performed using software IRW. Three-dimensional visualizations were performed using the OsiriX DICOM viewer. In mice experiments in vivo correlations nu / nu M, The A2780, PANC 1, MIA PaCa 2 and SKOV3 tumors were injected with 480 Ci 18F BO 20 and a PET-CT imaging 2 hours after injection. After imaging, the Mice get Were tet. The tissues were then harvested and weighed and the radioactivity was t gez Hlt. After the fusion of CT and PET images were Tumorr Founded modify SUVs to cover the entire tumor. The drawings are being guided by CT image analysis using the Siemens research application v3.0. Western blot of PARP 1/PARP 2 Expression After PET imaging, and gammaz Hlung were homogenized tumors in 400 l of 1 radioimmunotherapeutic
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