In mouse brain profilin I and II associate with regulators of the endocytic pathway and actin assembly Introduction The actin-binding protein profilin is thought to be a key regulator of actin polymerization in cells. Profilin binds to G-actin in a 1:1 complex and thereby sequesters monomeric actin. Upon binding to actin monomers, profilin acts
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Stage I research of temsirolimus in combination with EKB-569 in individuals with state-of-the-art sound tumors. Source Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ, 85255, USA, bryce.alan@mayo.edu. Abstract Objective Activation of EGFR can promote proliferative and survival signaling through mTOR. Preclinical data demonstrates synergistic action of combined EGFR and mTOR inhibition. We undertook a phase
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Bekaii-Saab T, Phelps MA, Li X, Saji M, Goff L, Kauh JS, O’Neil BH, Balsom S, Balint C, Liersemann R, Vasko VV, Bloomston M, Marsh W, Doyle LA, Ellison G, Grever M, Ringel MD, Villalona-Calero MA. “J Clin Oncol. 2011 Jun” PURPOSE: Biliary cancers (BCs) carry a poor prognosis, but targeting the RAS/RAF/mitogen-activated protein kinase
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