However, some cancer cells are intrinsically resistant and also the drug-exposed cancer cells often get a resistance. Discovery and exploitation of structurally different new categories of antimicrotubule agents may triumph over such problem. For example, the clinical utility with structurally different MT stabilizers to help overcome the Taxol-resistance has been reported. The complementary approaches may
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In mouse brain profilin I and II associate with regulators of the endocytic pathway and actin assembly Introduction The actin-binding protein profilin is thought to be a key regulator of actin polymerization in cells. Profilin binds to G-actin in a 1:1 complex and thereby sequesters monomeric actin. Upon binding to actin monomers, profilin acts
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Through its action in synthesizing telomere repeats, telomerase is required to maintain progenitor cell viability together with self-renewal. In settings associated with insufficient telomerase, telomere shortening blunts stalk cell self-renewal, dramatically impairing tissue function. In addition to the present telomere maintenance function, beta-Catenin Antibody, TERT, that telomerase protein catalytic subunit, are able to directly enhance
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