Archive for January, 2012:

Anti-beta-tubulin and anti-cancer action of Celastrol enhance the mitotic mobile

However, some cancer cells are intrinsically resistant and also the drug-exposed cancer cells often get a resistance. Discovery and exploitation of structurally different new categories of antimicrotubule agents may triumph over such problem. For example, the clinical utility with structurally different MT stabilizers to help overcome the Taxol-resistance has been reported. The complementary approaches may

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Mouse Beta-actin Antibody – Profilin II is mainly expressed in mouse brain

In mouse brain profilin I and II associate with regulators of the endocytic pathway and actin assembly Introduction   The actin-binding protein profilin is thought to be a key regulator of actin polymerization in cells. Profilin binds to G-actin in a 1:1 complex and thereby sequesters  monomeric actin. Upon binding to actin monomers, profilin acts

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Chondrocytes found in the articular cartilage of joints are under influence of Anti-beta-catenin signalling

Through its action in synthesizing telomere repeats, telomerase is required to maintain progenitor cell viability together with self-renewal. In settings associated with insufficient telomerase, telomere shortening blunts stalk cell self-renewal, dramatically impairing tissue function. In addition to the present telomere maintenance function, beta-Catenin Antibody, TERT, that telomerase protein catalytic subunit, are able to directly enhance

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