Antitumour exercise of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Scher Hi, Beer TM, Higano Do, Anand A, Taplin ME, Efstathiou E, Rathkopf D, Shelkey J, Yu EY, Alumkal J, Hung D, Hirmand M, Seely L, Morris MJ, Danila DC, Humm J, Larson S, Fleisher M, Sawyers CL; Prostate Cancer Foundation/Department of Protection
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Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods. Source Inserm UMR-S 973/MTi, University Paris Diderot, Paris, France. Abstract Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with
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Drug-Like chemical substances, recombinant proteinsIn 2009, Ding and colleagues demonstrated a prosperous option to transcription issue reprogramming by means of the use of drug-like chemical substances. This was the first method in human cells that was mechanism-specific for the reprogramming approach. Ding tackled the problem of genomic insertion by applying purified proteins to transform adult
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