The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis

Babashah, S. and M. Soleimani (2011). “The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.” Eur J Cancer.
MicroRNAs (miRNAs) are tiny, non-coding, endogenous RNAs that regulate gene expression in the post-transcriptional degree. MiRNAs perform essential roles in regulating many different biological process for instance proliferation, differentiation and apoptosis. It has been demonstrated that miRNAs possess a critical function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. As numerous studies have underlined the probable contribution of miRNAs to promote or evade apoptosis, it appears that the dysregulation of miRNAs associated with apoptosis could offer a mechanism for cancer development. Provided rising evidence that points to oncogenic and tumour suppressive roles of miRNAs in cancer and apoptosis, it’s believed that manipulating miRNA expression level may be a possible therapeutic method for curing cancer.


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